Dornase aerosol effect on sputum viscosity in cases of cystic fibrosis
J Lieberman - Jama, 1968 - jamanetwork.com
To the Editor:—Deoxyribonucleic acid is not normally present in mucoid respiratory
secretions but is a product of pulmonary inflammatory cellular debris. 1, 2 The DNA in
mucopurulent secretions seems to contribute to the chronicity of respiratory disease by
increasing the viscosity of such secretions. A therapeutic attack upon the DNA content of
purulent respiratory secretions would therefore appear to be worthwhile in an attempt to
reduce morbidity from respiratory infection and to enhance the effectiveness of antibiotics. 3 …
secretions but is a product of pulmonary inflammatory cellular debris. 1, 2 The DNA in
mucopurulent secretions seems to contribute to the chronicity of respiratory disease by
increasing the viscosity of such secretions. A therapeutic attack upon the DNA content of
purulent respiratory secretions would therefore appear to be worthwhile in an attempt to
reduce morbidity from respiratory infection and to enhance the effectiveness of antibiotics. 3 …
